142707-89-9

Upstream product

• 130336-10-6 (2S,4S)-3-oxa-2-butyl-4-<<4-(1,3-dioxabutyl)piperidin-1-yl>carbonyl>-5-phenylpentanoic acid 
• 142688-54-8 N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide 
• 161316-18-3 N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-2-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl)methyl)-3-methylbutanamide 
• 129921-93-3 2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid 
• 46460-73-5 N-benzyloxycarbonyl-1,3-diaminopropane 

Downstream Products

• 142707-90-2 A-78030 
• 142708-10-9 N-[3-(S-methyl-N'-cyanoisothioureido)propyl]-(2S,4S,5S,1'S,2'S)-5-[2-(1-{[4-(methoxymethoxy)piperidin-1-yl]carbonyl}-2-phenylethoxy)hexanamido]-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide 
• 1026275-59-1 (2S,4S,5S)-5-{(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid {3-[(imidazole-1-carbothioyl)-amino]-propyl}-amide 

Relevant academic research and scientific papers

Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog

The aim of this study was the discovery of nonpeptide renin inhibitors with much improved oral absorption, bioavailability, and efficacy, for use as antihypertensive agents. Our prior efforts led to the identification of A- 74273 [1, R = 3-(4-morpholino)p