161316-18-3

Upstream product

• 46460-73-5 N-benzyloxycarbonyl-1,3-diaminopropane 
• 129921-93-3 2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid 

Downstream Products

• 142688-57-1 N-(3-Aminopropyl) 2(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)methyl)-3-methylbutanamide 
• 142707-89-9 [3-((2S,4S,5S)-5-{(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoylamino)-propyl]-carbamic acid benzyl ester 
• 1026275-59-1 (2S,4S,5S)-5-{(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid {3-[(imidazole-1-carbothioyl)-amino]-propyl}-amide 
• 142708-10-9 N-[3-(S-methyl-N'-cyanoisothioureido)propyl]-(2S,4S,5S,1'S,2'S)-5-[2-(1-{[4-(methoxymethoxy)piperidin-1-yl]carbonyl}-2-phenylethoxy)hexanamido]-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide 
• 142707-90-2 A-78030 
• 142688-54-8 N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide 

Relevant academic research and scientific papers

Renin inhibitors

A renin inhibiting compound of the formula: STR1 wherein X is O, NH or S and G is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof; with the proviso that the compound is not N-(3-(4-M

Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog

The aim of this study was the discovery of nonpeptide renin inhibitors with much improved oral absorption, bioavailability, and efficacy, for use as antihypertensive agents. Our prior efforts led to the identification of A- 74273 [1, R = 3-(4-morpholino)p