14271-34-2

Basic information

• Product Name: 2-Butenoic acid, 3-(4-methylphenyl)-
• CAS NO: 14271-34-2
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 14271-34-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-(4-methylphenyl)-(14271-34-2)
• EPA Substance Registry System: 2-Butenoic acid, 3-(4-methylphenyl)-(14271-34-2)

Safety Data

• Hazardous Substances Data: 14271-34-2(Hazardous Substances Data)

Upstream product

• 3724-65-0 2-butenoic acid 
• 122-00-9 para-methylacetophenone 
• 94853-53-9 ethyl 3-(4-methylphenyl)-2-butenoate 
• 623-48-3 ethyl iodoacetae 

Downstream Products

• 14161-83-2 1-phenyl-3-(p-tolyl)but-2-en-1-one 
• 39027-57-1 3-(4-methylphenyl)butanoic acid 
• 1619940-93-0 (E)-1-methyl-4-(4,4,4-trifluorobut-2-en-2-yl)benzene 
• 947383-46-2 (E)-1-methyl-4-(1-nitroprop-1-en-2-yl)benzene 
• 1427204-62-3 C₁₄H₁₆N₂OS 
• 144782-30-9 (E)-3-(4-methylphenyl)but-2-enoyl chloride 
• 39599-18-3 6-(p-tolyl)-2-methyl-2-heptanol, trans- 
• 6090-01-3 3-(p-tolyl)-1-butanol 
• 43208-94-2 1-Iod-3-p-tolylbutan 
• 122-00-9 para-methylacetophenone 
• 34335-30-3 3-(4-carboxy-phenyl)-butyric acid 
• 4981-38-8 3-hydroxy-3-p-tolyl-butyric acid 
• 1195-32-0 1-methyl-4-isopropenylbenzene 

Relevant articles and documents

Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed [3 + 2] Annulation of Vinyl Enolates with 1-Tosyl-2-vinylaziridine

The synergistic combination of N-heterocyclic carbene organocatalysis and transition-metal catalysis for a formal [3 + 2] annulation between 3-substituted but-2-enoates and 1-tosyl-2-vinylaziridine was developed. This cooperative strategy provides a facile and efficient access to various functionalized (E)-3-ethylidene-4-vinylpyrrolidin-2-ones in a regioselective and stereoselective manner. The preliminary asymmetric studies were also performed, which indicated a potential for enantioselective annulation of vinyl enolate intermediates with transition-metal-π-allyl species.

Iridium(III)-Catalyzed Direct Arylation of C-H Bonds with Diaryliodonium Salts

By developing a new Ir(III)-catalyzed C-C cross-coupling, a versatile method for direct arylation of sp2 and sp3 C-H bonds in ketoximes, nitrogen-containing heterocycles, various arenes, and olefins has been established. The key to this arylation depends on the appropriate choice of catalyst and the use of diaryliodonium triflate salts as the coupling partners. This transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage C-H arylation of complex compounds. Mechanistic studies by density functional theory calculations suggested that the sp3 C-H activation was realized by a triflate-involved concerted metalation-deprotonation process, and the following oxidation of Ir(III) to Ir(V) is the most favorable when a bistriflimide is contained in the diaryliodonium salt. Calculations indicated that both steps are enabled by initial anion exchange between the reactant complexes.

N-heterocyclic carbene-catalyzed cyclization of unsaturated acyl chlorides and ketones

A straightforward synthesis of optically active trifluoromethyl dihydropyranones and spirocyclic oxindole-dihydropyranones has been realized by the chiral N-heterocyclic carbenes-catalyzed cyclization of α,β- unsaturated β-methylacyl chlorides with activated trifluoromethyl ketones or isatin derivatives. Copyright