1427158-06-2Relevant articles and documents
Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles
Holmes, Jane L.,Almeida, Lynsie,Barlaam, Bernard,Croft, Rosemary A.,Dishington, Allan P.,Gingipalli, Laksmaiah,Hassall, Lorraine A.,Hawkins, Janet L.,Ioannidis, Stephanos,Johannes, Jeffrey W.,McGuire, Thomas M.,Moore, Jane E.,Patel, Anil,Pike, Kurt G.,Pontz, Timothy,Wu, Xiaoyun,Wang, Tao,Zhang, Hai-Jun,Zheng, Xiaolan
, p. 1226 - 1234 (2016/05/19)
Examples of hydroxymethylated analogues of heteroaryl cores such as quinazolin-4-ones, isoquinolin-1(2H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, chromen-4-ones and pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones are sparse or non-existent in the scientific literature. We have demonstrated that such compounds are accessible by using standard procedures from readily available raw materials.
Pyrimidinone nicotinamide mimetics as selective tankyrase and Wnt pathway inhibitors suitable for in vivo pharmacology
Johannes, Jeffrey W.,Almeida, Lynsie,Barlaam, Bernard,Boriack-Sjodin, P. Ann,Casella, Robert,Croft, Rosemary A.,Dishington, Allan P.,Gingipalli, Lakshmaiah,Gu, Chungang,Hawkins, Janet L.,Holmes, Jane L.,Howard, Tina,Huang, Jian,Ioannidis, Stephanos,Kazmirski, Steven,Lamb, Michelle L.,McGuire, Thomas M.,Moore, Jane E.,Ogg, Derek,Patel, Anil,Pike, Kurt G.,Pontz, Timothy,Robb, Graeme R.,Su, Nancy,Wang, Haiyun,Wu, Xiaoyun,Zhang, Hai-Jun,Zhang, Yue,Zheng, Xiaolan,Wang, Tao
, p. 254 - 259 (2015/03/30)
The canonical Wnt pathway plays an important role in embryonic development, adult tissue homeostasis, and cancer. Germline mutations of several Wnt pathway components, such as Axin, APC, and ?-catenin, can lead to oncogenesis. Inhibition of the poly(ADP-r
PYRROLOTRIAZINONE DERIVATIVES
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Page/Page column 56, (2013/11/19)
Compounds of the formula (I) in which X, R1 and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase and PARP-1 and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of imflamination.
A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo[2,1-f][1,2,4] triazin-4(3H)-ones
Chen, Yanhong,Xiang, Haoyue,Tan, Cun,Xie, Yuyuan,Yang, Chunhao
, p. 2714 - 2719 (2013/03/28)
An efficient tandem method for the annulation of 1-amino-1H-pyrrole-2- amides with various substituted benzaldehydes, heteroaryl aldehydes, alkyl aldehydes or even acetals, promoted by cupric chloride, to synthesize 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones is reported. This approach provides a useful method for constructing the privileged structure in medicinal chemistry. Electron-donating groups on both partners could accelerate the reaction.
