1427158-07-3

Basic information

• Product Name: 4-(4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)benzoic acid methyl ester
• Synonyms: 4-(4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)benzoic acid methyl ester
• CAS NO: 1427158-07-3
• Molecular Weight: 269.26
• Mol File: 1427158-07-3.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)benzoic acid methyl ester(1427158-07-3)
• EPA Substance Registry System: 4-(4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)benzoic acid methyl ester(1427158-07-3)

Safety Data

• Hazardous Substances Data: 1427158-07-3(Hazardous Substances Data)

Upstream product

• 586-75-4 4-chlorobenzoyl chloride 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 1427158-06-2 2-(4-bromophenyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 159326-69-9 1-aminopyrrole-2-carboxamide 
• 1571-08-0 methyl 4-formylbenzoate 

Relevant articles and documents

PYRROLOTRIAZINONE DERIVATIVES

Compounds of the formula (I) in which X, R1 and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase and PARP-1 and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of imflamination.

A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo[2,1-f][1,2,4] triazin-4(3H)-ones

An efficient tandem method for the annulation of 1-amino-1H-pyrrole-2- amides with various substituted benzaldehydes, heteroaryl aldehydes, alkyl aldehydes or even acetals, promoted by cupric chloride, to synthesize 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones is reported. This approach provides a useful method for constructing the privileged structure in medicinal chemistry. Electron-donating groups on both partners could accelerate the reaction.