1427162-34-2Relevant academic research and scientific papers
Acylhydrazide Schiff bases: DPPH radical and superoxide anion scavengers
Khan, Khalid Mohammed,Taha, Muhammad,Naz, Farzana,Siddiqui, Salman,Ali, Sajjad,Rahim, Fazal,Perveen, Shahnaz,Choudhary, M. Iqbal
, p. 705 - 710 (2012/09/08)
Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25-473.59 μM. Compounds 8, 2, and 10 have IC50 values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 μM, respectively. Standard npropylgallate showed an IC50 value 30.12 ± 0.27 μM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6-450.89 μM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 ± 1.6 μM).
