18362-36-2

Usage

Uses

Used in the Food Industry:
6-Methylsalicylaldehyde is used as a flavoring agent for its distinctive floral and sweet aroma, enhancing the taste and scent of various food products.
Used in Perfumes and Cosmetic Products:
In the fragrance industry, 6-Methylsalicylaldehyde serves as an ingredient to impart a pleasant and complex scent to perfumes and cosmetic products, adding depth and character to their olfactory profiles.
Used in Pharmaceutical Synthesis:
6-Methylsalicylaldehyde is utilized as a starting material in the synthesis of pharmaceuticals, contributing to the development of new drugs and medicinal compounds.
Used in Organic Compound Preparation:
6-Methylsalicylaldehyde also plays a role in the preparation of various organic compounds, serving as a versatile building block in organic chemistry.
Used in Antimicrobial Applications:
6-Methylsalicylaldehyde exhibits antimicrobial properties, making it a potential candidate for use in products that require bacterial control or prevention of microbial growth.
Used in Antioxidant Applications:
Due to its antioxidant properties, 6-Methylsalicylaldehyde can be employed in applications where protection against oxidative damage is necessary, such as in certain industrial processes or in the formulation of certain products.
It is important to handle 6-Methylsalicylaldehyde with care, as it may cause skin and eye irritation and is classified as a flammable substance. Proper safety measures should be taken during its use and storage to mitigate any potential risks.

Upstream product

• 67-66-3 chloroform 
• 108-39-4 3-methyl-phenol 
• 75-25-2 Bromoform 
• 54884-55-8 2-methoxy-6-methyl-benzaldehyde 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 71-43-2 benzene 
• 53300-10-0 2-amino-4-methyl-cycloheptatrienone 
• 940003-50-9 3-methyl-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 68-12-2 N,N-dimethyl-formamide 
• 2944-49-2 2,3-dimethylanisole 
• 4885-02-3 Dichloromethyl methyl ether 
• 138308-77-7 2-(1,3-dimethylimidazolidin-2-yl)phenol 
• 74-88-4 methyl iodide 

Downstream Products

• 29922-52-9 2-hydroxymethyl-3-methylphenol 
• 526-75-0 2,3-Dimethylphenol 
• 51985-20-7 3,6-dihydroxy-2-methyl-benzaldehyde 
• 567-61-3 2-hydroxy-6-methylbenzoic acid 
• 140141-57-7 C₃₀H₂₈N₂O₂ 
• 1078728-89-8 2-[(4-bromo-2-fluorophenyl)iminomethyl]-3-methylphenol 
• 875110-19-3 2-(benzyloxy)-6-methylbenzaldehyde 
• 1360618-17-2 4-[(2-formyl-3-methylphenoxy)methyl]benzoic acid methyl ester 
• 1360618-29-6 4-((2-formyl-3-methylphenoxy)methyl)benzoic acid 
• 1360618-27-4 C₂₅H₃₅NO₆Si 
• 1380519-91-4 2-((11-hydroxyundecyl)oxy)-6-methylbenzaldehyde oxime 
• 887925-54-4 5-methyl-3-phenyl-2H-chromen-2-one 
• 1607446-96-7 2-(2-hydroxy-6-methylphenyl)-1-phenylpropan-1-one 
• 1607446-92-3 (E)-4-(2-hydroxy-6-methylphenyl)-1-phenylpent-1-en-3-one 

Relevant academic research and scientific papers

Phytochemical study on American plants I. Two new phenol glucosides, together with known biflavones and diterpene, from leaves of Juniperus occidentalis Hook.

Two new phenol glucosides termed juniperosides I (1) and II (2) were isolated, together with known two biflavones, cupressuflavone and amentoflavone and a diterpene, 3beta-hydroxy sandaracopimaric acid, from leaves of Juniperus occidentalis HOOK. (Cupress

A theoretical study of the Duff reaction: Insights into its selectivity

The Duff reaction is one of the most employed methods for the ortho-formylation of phenols; however, not much is truly known about its mechanism. Using DFT calculations, we disclose the first theoretical study regarding the selectivity-determining step of the reaction. We have found that this stage is governed by a hydrogen bond, that gives rise to a cyclohexa-2,4-dienone intermediate and establishes the position where the formylation will take place. These findings were evaluated by analysis of the reaction outcome of several non-symmetrically substituted phenols.

Polymerizable Materials Based On Dimerizable Benzaldehyde Derivatives

The present invention relates to polymerizable and photochemically crosslinkable compositions which contain at least one polymerizable benzaldehyde derivative according to general formula I and which are suitable as materials for technical and medical app

On-demand acid-gated fluorescence switch-on in photo-generated nanospheres

Herein, we introduce a fast, additive-free, ambient temperature photochemical approach - utilising the novel Diels-Alder cycloaddition of a photo-activeortho-methylbenzaldehyde (oMBA) with a terminal alkyne - for preparing functional acid-sensitive proflu

DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES

The present invention relates to small molecule compounds and their use as agonists of farnesoid X receptor (FXR) and/or peroxisome proliferator activated receptor delta (PPARδ). The present invention also relates to the use of said compounds in the treatment of metabolic diseases and respective methods of treatment.

Protection-Group-Free Synthesis of Sequence-Defined Macromolecules via Precision λ-Orthogonal Photochemistry

An advanced light-induced avenue to monodisperse sequence-defined linear macromolecules via a unique photochemical protocol is presented that does not require any protection-group chemistry. Starting from a symmetrical core unit, precision macromolecules

Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers

Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.

A Combined Photochemical and Multicomponent Reaction Approach to Precision Oligomers

We introduce the convergent synthesis of linear monodisperse sequence-defined oligomers through a unique approach, combining the Passerini three-component reaction (P-3CR) and a Diels–Alder (DA) reaction based on photocaged dienes. A set of oligomers is prepared resting on a Passerini linker unit carrying an isocyano group for chain extension by P-3CR and a maleimide moiety for photoenol conjugation enabling a modular approach for chain growth. Monodisperse oligomers are accessible in a stepwise fashion by switching between both reaction types. Employing sebacic acid as a core unit allows the synthesis of a library of symmetric sequence-defined oligomers. The oligomers consist of alternating P-3CR and photoblocks with molecular weights up to 3532.16 g mol?1, demonstrating the successful switching from P-3CR to photoenol conjugation. In-depth characterization was carried out including size-exclusion chromatography (SEC), high-resolution electrospray ionization mass spectrometry (ESI-MS) and NMR spectroscopy, evidencing the monodisperse nature of the precision oligomers.

Synthesis of Benzofuranones via Palladium-Catalyzed Intramolecular Alkoxycarbonylation of Alkenylphenols

Herein, a new catalytic system to synthesize benzofuranones is reported. A palladium-catalyzed intramolecular alkoxycarbonylation is employed to generate 3-substituted-benzofuran-2(3H)-ones from alkenylphenols under mild reaction conditions, linked to an ex situ formation of CO from N-formylsaccharin. The carefully chosen catalytic system enables an efficient reaction with a novel functional group tolerance, despite the high polymerization tendency of the starting material.

Star polymer synthesis: Via λ-orthogonal photochemistry

We introduce a light induced sequence enabling λ-orthogonal star polymer formation via an arms-first approach, based on an α,ω-functional polymer carrying tetrazole and o-methyl benzaldehyde moieties, which upon irradiation can readily undergo cycloaddition with a trifunctional maleimide core. Depending on the wavelength, the telechelic strand can be attached to the core at either photo-reactive end.