1427266-37-2

Basic information

• Product Name: C₂₂H₂₁NO
• Synonyms: C₂₂H₂₁NO
• CAS NO: 1427266-37-2
• Molecular Weight: 315.415
• Mol File: 1427266-37-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁NO(1427266-37-2)
• EPA Substance Registry System: C₂₂H₂₁NO(1427266-37-2)

Safety Data

• Hazardous Substances Data: 1427266-37-2(Hazardous Substances Data)

Upstream product

• 582-22-9 2-phenylpropylamine 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 

Downstream Products

• 1427266-40-7 C₂₃H₂₁NO 

Relevant articles and documents

Silica-supported polyphosphoric acid in the synthesis of 4-substituted tetrahydroisoquinoline derivatives

We report herein an application of an α-amidoalkylation reaction, as an alternative efficient synthesis of 4-aryl- and 4-methyl-1,2,3,4- tetrahydroisoquinoline derivatives. The amides required for this purpose would result from reaction of aminoacetaldehyde dimethylacetal with different substituted benzenes in polyphosphoric acid, followed by acylation of the obtained amines with different acid chlorides or sulfochlorides. We compared the cyclisation step using conventional (milieu of acetictrifluoracetic acid = 4:1) and solid supported reagents (SiO2/PPA), as recovered, regenerated and reused without loss of its activity catalyst. We found that in comparison to conventional methods, the yields of the reaction are greater and the reaction time is shorter.