142730-58-3Relevant academic research and scientific papers
Enzymatic resolution of 1,2-diols: Preparation of optically pure dropropizine
Bianchi,Bosetti,Cesti,Golini
, p. 3231 - 3234 (1992)
Kinetic resolution of (R,S)-3-(4-phenyl-1-piperazinyl)-1,2-propranediol diacetate (2) by alcoholysis with n-propanol was carried out under lipase Amano PS catalysis in various organic solvents. Pure enantiomers of the corresponding diol (1) are useful as antitussive and central sedative therapeutic agents.
