Enzymatic resolution of 1,2-diols: Preparation of optically pure dropropizine

DOI: 10.1016/S0040-4039(00)79859-5

Source and publish data:

Tetrahedron Letters p. 3231 - 3234 (1992)

Update date:2022-08-03

Topics:

Authors:

Bianchi Bianchi

Bosetti Bosetti

Cesti Cesti

Golini Golini

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Article abstract of DOI:10.1016/S0040-4039(00)79859-5

Kinetic resolution of (R,S)-3-(4-phenyl-1-piperazinyl)-1,2-propranediol diacetate (2) by alcoholysis with n-propanol was carried out under lipase Amano PS catalysis in various organic solvents. Pure enantiomers of the corresponding diol (1) are useful as antitussive and central sedative therapeutic agents.

Full text of DOI:10.1016/S0040-4039(00)79859-5

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