Enzymatic resolution of 1,2-diols: Preparation of optically pure dropropizine

Article abstract of DOI:10.1016/S0040-4039(00)79859-5

Kinetic resolution of (R,S)-3-(4-phenyl-1-piperazinyl)-1,2-propranediol diacetate (2) by alcoholysis with n-propanol was carried out under lipase Amano PS catalysis in various organic solvents. Pure enantiomers of the corresponding diol (1) are useful as antitussive and central sedative therapeutic agents.