Tetrahedron Letters p. 3231 - 3234 (1992)
Update date:2022-08-03
Topics:
Bianchi
Bosetti
Cesti
Golini
Kinetic resolution of (R,S)-3-(4-phenyl-1-piperazinyl)-1,2-propranediol diacetate (2) by alcoholysis with n-propanol was carried out under lipase Amano PS catalysis in various organic solvents. Pure enantiomers of the corresponding diol (1) are useful as antitussive and central sedative therapeutic agents.
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