1427407-23-5

Basic information

• Product Name: 3-amino-2-chloro-4-fluorophenol
• Synonyms: 3-amino-2-chloro-4-fluorophenol
• CAS NO: 1427407-23-5
• Molecular Weight: 161.563
• Mol File: 1427407-23-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-amino-2-chloro-4-fluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-chloro-4-fluorophenol(1427407-23-5)
• EPA Substance Registry System: 3-amino-2-chloro-4-fluorophenol(1427407-23-5)

Safety Data

• Hazardous Substances Data: 1427407-23-5(Hazardous Substances Data)

Upstream product

• 1017777-58-0 2-chloro-6-fluoro-3-methoxy-aniline 
• 2267-25-6 2-chloro-4-fluoro-1-methoxy-benzene 
• 886499-40-7 2-chloro-6-fluoro-3-methoxy-benzoic acid 

Downstream Products

• 1427407-24-6 N-(2-chloro-6-fluoro-3-hydroxy-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide 
• 1427407-25-7 2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol 
• 1427407-26-8 C₂₃H₁₉ClF₃NO₃ 
• 1427406-15-2 2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid 

Relevant articles and documents

QUINAZOLINE COMPOUNDS

The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.