1427446-94-3Relevant academic research and scientific papers
FACTOR XIa INHIBITORS
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Page/Page column 36, (2017/05/21)
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
Base-catalyzed synthesis of substituted indazoles under mild, transition-metal-free conditions
Thome, Isabelle,Besson, Claire,Kleine, Tillmann,Bolm, Carsten
, p. 7509 - 7513 (2013/07/26)
Back to basics: A transition-metal-free method developed for the synthesis of indazoles involves an inexpensive catalytic system composed of a diamine and K2CO3. Various (Z)-2-bromoacetophenone tosylhydrazones were converted into indazoles at room temperature in excellent yields (see example; Ts=p-toluenesulfonyl). The yield was improved by photoisomerization with UV light when E/Z isomeric mixtures of the starting material were used. Copyright
