1427521-86-5

Basic information

• Product Name: (R)-4-(((benzyloxy)carbonyl)amino)-1-(tert-butoxy)-1-oxobutan-2-yl 4-nitrobenzoate
• Synonyms: (R)-4-(((benzyloxy)carbonyl)amino)-1-(tert-butoxy)-1-oxobutan-2-yl 4-nitrobenzoate
• CAS NO: 1427521-86-5
• Molecular Weight: 458.468
• Mol File: 1427521-86-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-4-(((benzyloxy)carbonyl)amino)-1-(tert-butoxy)-1-oxobutan-2-yl 4-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(((benzyloxy)carbonyl)amino)-1-(tert-butoxy)-1-oxobutan-2-yl 4-nitrobenzoate(1427521-86-5)
• EPA Substance Registry System: (R)-4-(((benzyloxy)carbonyl)amino)-1-(tert-butoxy)-1-oxobutan-2-yl 4-nitrobenzoate(1427521-86-5)

Safety Data

• Hazardous Substances Data: 1427521-86-5(Hazardous Substances Data)

Upstream product

• 62-23-7 4-nitro-benzoic acid 
• 849773-54-2 tert-butyl (2S)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate 
• 501-53-1 benzyl chloroformate 
• 40371-50-4 S-4-benzyloxycarbonylamino-2-hydroxybutyric acid 

Downstream Products

• 1427521-87-6 tert-butyl (2R)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate 
• 1428203-72-8 (R,Z)-tert-butyl 4-((6,7-bis(benzyloxy)-3-((tert-butoxycarbonyl)amino)quinolin-2(1H)-ylidene)amino)-2-hydroxybutanoate 
• 1428203-72-8 (R,E)-tert-butyl 4-((6,7-bis(benzyloxy)-3-((tert-butoxycarbonyl)amino)quinolin-2(1H)-ylidene)amino)-2-hydroxybutanoate 

Relevant articles and documents

Buchwald-Hartwig versus Microwave-Assisted Amination of Chloroquinolines: En Route to the Pyoverdin Chromophore

The reaction of 2-chloro-6,7-dimethoxy-3-nitroquinoline with a series of amines and aminoalkanoates under basic microwave-mediated conditions and under Buchwald-Hartwig amination conditions is reported. The microwave irradiation favored the reaction with amines, resulting in yields of up to 80percent, whereas amino acid functionalization gave yields comparable to those of Buchwald-Hartwig amination. tert-Butyl (2 R)-4-[(6,7-dimethoxy-3-nitroquinolin-2-yl)amino]-2-hydroxybutanoate was successfully cyclized to the pyoverdin chromophore, a subunit of siderophores.