142761-11-3

Basic information

• Product Name: R-(-)-O-DESMETHYLVENLAFAXINE
• Synonyms: Desvenlafaxine R-Isomer;(R)-Desmethyl Venlafaxine D6;R-(-)-O-Desvenlafaxine;Venlafaxine O-Desmethyl R-Isomer
• CAS NO: 142761-11-3
• Molecular Formula: C₁₆H₂₅NO₂
• Molecular Weight: 263.379
• Product Categories: Various Metabolites and Impurities;Metabolites
• Mol File: 142761-11-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 208-213°C
• Boiling Point: 403.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.115±0.06 g/cm3(Predicted)
• Refractive Index: 1.573
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• PKA: 10.04±0.26(Predicted)
• CAS DataBase Reference: R-(-)-O-DESMETHYLVENLAFAXINE(CAS DataBase Reference)
• NIST Chemistry Reference: R-(-)-O-DESMETHYLVENLAFAXINE(142761-11-3)
• EPA Substance Registry System: R-(-)-O-DESMETHYLVENLAFAXINE(142761-11-3)

Safety Data

• Hazardous Substances Data: 142761-11-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 142761-11-3 differently. You can refer to the following data:
1. A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant. It can also be used to treat sleep-related breathing disorders.
2. R-(-)-O-DesMethyl Venlafaxine is a metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor,it is used as an antidepressant.

InChI:InChI=1/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3/t15-/m0/s1

Upstream product

• 99300-78-4 venlafaxine hydrochloride 
• 272788-00-8 (R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol-hemi-D-di-p-toluoyltartrate 
• 50-00-0 formaldehyd 
• 93413-44-6 (R)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol 
• 272788-00-8 1-((R)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl) cyclohexanol hemi-ditoluoyl tartrate 

Downstream Products

• 1049700-94-8 (-)-O-desmethylvenlafaxine hydrochloride 

Relevant articles and documents

Carboxylate Salt Bridge-Mediated Enamine Catalysis: Expanded Michael Reaction Substrate Scope and Facile Access to Antidepressant (R)-Pristiq

We report broad guidance on how to catalyze enantioselective aldehyde additions to nitroalkene or maleimide Michael electrophiles in the presence of unprotected acidic spectator groups, e.g., carboxylic acids, acetamides, phenols, catechols, and maleimide

N-OXIDES OF VENLAFAXINE AND O-DESMETHYLVENLAFAXINE AS PRODRUGS

Embodiments of the invention relate to a compound of formula (1), or a tautomer, stereoisomer, hydrate, or solvate thereof, wherein R1 is H or CH3. Other embodiments of the invention relate to a pharmaceutical composition containing these compound, to methods for preparing these compounds, and to methods for preparing compositions containing these compounds. Yet other embodiments of the invention relate to the uses of these compounds and compositions containing it, such as for the manufacture of medicaments and pharmaceutical compositions for treating a condition chosen from depression, major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social anxiety disorder, panic disorder, general depressive disorders, diabetic neuropathy, migraine and hot flashes.

COMBINATIONS OF ESZOPICLONE AND O-DESMETHYLVENLAFAXINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component