142764-70-3

Usage

Uses

Used in Pharmaceutical Industry:
1-CBZ-2-PROPYL-PIPERIDIN-4-ONE is used as an intermediate in the synthesis of various medications for its ability to be incorporated into the molecular structures of different pharmaceutical compounds. Its properties allow it to contribute to the development of a wide range of therapeutic agents.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 1-CBZ-2-PROPYL-PIPERIDIN-4-ONE is utilized as a key component in the creation of diverse organic compounds. Its reactivity and structural features make it suitable for use in the synthesis of complex organic molecules for various applications.
Used in Research Chemicals Production:
1-CBZ-2-PROPYL-PIPERIDIN-4-ONE is also employed as an intermediate in the production of research chemicals, facilitating scientific investigations and the development of new chemical entities for potential applications in medicine, materials science, and other fields.

Upstream product

• 142764-67-8 N-<(S)-1-carboxy-(S)-2-methylbutyl>-(6S)-2,3-didehydro-6-n-propylpiperidin-4-one 
• 132599-74-7 N-<(S)-1-(methoxycarbonyl)-(S)-2-methylbutyl>-(6S)-2,3-didehydro-6-n-propylpiperidin-4-one 
• 132599-85-0 [(S)-2-Methyl-1-((S)-4-oxo-2-propyl-3,4-dihydro-2H-pyridin-1-yl)-butyl]-carbamic acid benzyl ester 
• 620-08-6 4-methoxypyridine 
• 501-53-1 benzyl chloroformate 
• 927-77-5 n-propylmagnesium bromide 
• 185847-84-1 benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate 
• 132599-74-7 (S)-3-Methyl-2-((S)-4-oxo-2-propyl-3,4-dihydro-2H-pyridin-1-yl)-pentanoic acid methyl ester 
• 132599-85-0 [(1S,2S)-2-Methyl-1-((S)-4-oxo-2-propyl-3,4-dihydro-2H-pyridin-1-yl)-butyl]-carbamic acid benzyl ester 
• 132599-87-2 (6S)-2,3-didehydro-6-n-propylpiperidin-4-one 
• 142764-69-0 N-(benzyloxycarbonyl)-(6S)-2,3-didehydro-6-n-propylpiperidin-4-one 

Downstream Products

• 555-92-0 (S)-coniine hydrochloride 
• 934016-33-8 benzyl (S)-2-propylpiperidine-1-carboxylate 
• 142780-95-8 N-(benzyloxycarbonyl)-(6S)-4-(1,3-dithiolan-4-yl)-6-n-propylpiperidine 

Relevant academic research and scientific papers

Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors

General methods to prepare chiral N-heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2- and 4-substituted tetrahydro-quinolones, dihydro-4-pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.

Asymmetric Tandem Mannich-Michael Reactions of Amino Acid Ester Imines with Danishefsky's Diene

Imines 1 derived from aromatic, aliphatic, and functionalized aldehydes and various amino acid esters react with Danishefsky's diene under Lewis acid catalysis via a tandem Mannich-Michael mechanism to give cyclic 6-substituted 2,3-didehydro-4-piperidinones in good to high yields and with diastereomeric ratios reaching from 92:8 up to 97:3.The chiral auxiliary is removed by conversion of the α C atom of the amino acid into an acetalic center, employing a Curtius reaction as the key step.For the elucidation of the absolute configuration, the alkaloids (S)-coniine and (R)-δ-coniceine are synthesized from the enaminones 5i and 5r.