1427669-87-1Relevant academic research and scientific papers
Palladium-catalyzed C2-acylation of indoles with α-diketones assisted by the removable N-(2-pyrimidyl) group
Li, Chunpu,Zhu, Wei,Shu, Shuangjie,Wu, Xiaoming,Liu, Hong
, p. 3743 - 3750 (2015/06/16)
An effective and practical palladium-catalyzed C2-acylation method was successfully developed for the synthesis of 2-acylindoles. A variety of 2-acylindoles were readily prepared from N-pyrimidyl indoles in moderate to good yields. This methodology offers
Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: Pyrimidine as an easily removable C-H directing group
Kumar, Govindharaj,Sekar, Govindasamy
, p. 28292 - 28298 (2015/04/14)
Pyrimidine is successfully used as an easily removable C(sp2)-H directing group for the synthesis of 2-acyl indoles and 2,7-diacyl indoles through direct C-H functionalization using a Pd-catalyst from 1-(pyrimidin-2-yl)-1H-indoles and aldehydes. Easy removal of the pyrimidine directing group using EtONa in DMSO provides C2-acyl indoles.
Palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids
Pan, Changduo,Jin, Hongming,Liu, Xu,Cheng, Yixiang,Zhu, Chengjian
supporting information, p. 2933 - 2935 (2013/04/24)
A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles. The Royal Society of Chemistry 2013.
