1427744-25-9

Basic information

• Product Name: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-hydroxymethyl-pyrazin-2-yl)propionamide
• Synonyms: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-hydroxymethyl-pyrazin-2-yl)propionamide
• CAS NO: 1427744-25-9
• Molecular Weight: 437.947
• Mol File: 1427744-25-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-hydroxymethyl-pyrazin-2-yl)propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-hydroxymethyl-pyrazin-2-yl)propionamide(1427744-25-9)
• EPA Substance Registry System: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-hydroxymethyl-pyrazin-2-yl)propionamide(1427744-25-9)

Safety Data

• Hazardous Substances Data: 1427744-25-9(Hazardous Substances Data)

Upstream product

• 13924-94-2 5-amino-pyrazine-2-carboxylic acid methyl ester 
• 169335-35-7 5-fluoro-pyrazine-2-carboxylic acid methyl ester 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 

Downstream Products

• 710321-53-2 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-methanesulfonylmethyl-pyrazin-2-yl)-propionamide 

Relevant articles and documents

Identification of RO4597014, a glucokinase activator studied in the clinic for the treatment of type 2 diabetes

To resolve the metabolite redox cycling associated with our earlier clinical compound 2, we carried out lead optimization of lead molecule 1. Compound 4 showed improved lipophilic ligand efficiency and demonstrated robust glucose lowering in diet-induced obese mice without a liability in predictive preclinical drug safety studies. Thus, it was selected as a clinical candidate and further studied in type 2 diabetic patients. Clinical data suggests no evidence of metabolite cycling, which is consistent with the preclinical profiling of metabolism.