710321-53-2

Basic information

• Product Name: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-methanesulfonylmethyl-pyrazin-2-yl)-propionamide
• CAS NO: 710321-53-2
• Molecular Weight: 500.04
• Mol File: 710321-53-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-methanesulfonylmethyl-pyrazin-2-yl)-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-methanesulfonylmethyl-pyrazin-2-yl)-propionamide(710321-53-2)
• EPA Substance Registry System: 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-methanesulfonylmethyl-pyrazin-2-yl)-propionamide(710321-53-2)

Safety Data

• Hazardous Substances Data: 710321-53-2(Hazardous Substances Data)

Upstream product

• 1427744-25-9 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-hydroxymethyl-pyrazin-2-yl)propionamide 
• 13924-94-2 5-amino-pyrazine-2-carboxylic acid methyl ester 
• 169335-35-7 5-fluoro-pyrazine-2-carboxylic acid methyl ester 
• 1427744-12-4 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid methyl ester 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 

Relevant articles and documents

Identification of RO4597014, a glucokinase activator studied in the clinic for the treatment of type 2 diabetes

To resolve the metabolite redox cycling associated with our earlier clinical compound 2, we carried out lead optimization of lead molecule 1. Compound 4 showed improved lipophilic ligand efficiency and demonstrated robust glucose lowering in diet-induced obese mice without a liability in predictive preclinical drug safety studies. Thus, it was selected as a clinical candidate and further studied in type 2 diabetic patients. Clinical data suggests no evidence of metabolite cycling, which is consistent with the preclinical profiling of metabolism.