1427795-18-3

Basic information

• Product Name: C₃₇H₆₀O₄SSi
• Synonyms: C₃₇H₆₀O₄SSi
• CAS NO: 1427795-18-3
• Molecular Weight: 629.033
• Mol File: 1427795-18-3.mol

Chemical Properties

• CAS DataBase Reference: C₃₇H₆₀O₄SSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₆₀O₄SSi(1427795-18-3)
• EPA Substance Registry System: C₃₇H₆₀O₄SSi(1427795-18-3)

Safety Data

• Hazardous Substances Data: 1427795-18-3(Hazardous Substances Data)

Upstream product

• 20231-57-6 methyl 5-cholenoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 114011-35-7 3β-(t-butyldimethylsilyloxy)-5-cholenic acid methyl ester 
• 5255-17-4 3β-hydroxy-5-cholenoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 84529-86-2 (20R)-3β-(tert-butyldimethylsilyloxy)-24-hydroxy-25,26,27-trisnorcholest-5-ene 

Downstream Products

• 60816-17-3 (26,26,26,27,27,27-²H₆)cholesterol 

Relevant articles and documents

Biosynthesis of steroidal alkaloids in Solanaceae plants: Involvement of an aldehyde intermediate during C-26 amination

The C-26 amino group of steroidal alkaloids, such as tomatine, is introduced during an early step of their biosynthesis from cholesterol. In the present study, the mechanism of C-26 amination was reinvestigated by administering stable isotope labeled compounds, such as (26,26,26,27,27,27- 2H6)cholesterol during biosynthesis of tomatine, solanine and solasonine. The chemical compositions of tomatine and solanine so obtained were analyzed by LC-MS after administering the d6-cholesterol to a tomato seedling and a potato shoot, respectively. The resulting spectra indicated that two deuterium atoms were eliminated from C-26 of cholesterol during biosynthesis. Furthermore, administration of (6-13C 2H3)mevalonate in combination with lovastatin to an eggplant seedling, followed by GC-MS analysis of solasodine after TMS derivatization established that two deuterium atoms were eliminated from C-26 of cholesterol during solasonine biosynthesis. These findings are in contrast to an earlier observation that one hydrogen atom was lost from C-26 during tomatidine biosynthesis, and suggest that C-26 nitrogen atom addition involves an aldehyde intermediate. Thus, it is proposed that the C-26 amination reaction that occurs during steroidal alkaloid biosynthesis proceeds by way of a transamination mechanism.

Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement

Class F G protein-coupled receptors are characterized by a large extracellular domain (ECD) in addition to the common transmembrane domain (TMD) with seven α-helixes. For smoothened receptor (SMO), structural studies revealed dissected ECD and TMD, and th

Smooth receptor ligand

The invention relates to the technical field of biology, particularly to a smooth receptor ligand, and provides a smooth receptor ligand or an isomer prodrug, a solvate and a pharmaceutically acceptable salt thereof, wherein the structural formula of the smooth receptor ligand is A-linker-B, A is an extracellular domain ligand structure, B is a transmembrane domain ligand structure, and Linker isa linear subunit inactive to the smooth receptor. According to the novel double-end small molecule ligand for the smooth receptor, by combining the crystal structure data of the smooth receptor, a linker is introduced into the proper sites of an extracellular domain ligand and a transmembrane domain ligand to obtain brand-new double-end ligand small molecules, so that the interaction between the ligand and the receptor and the biological activity of the ligand are enhanced.