142793-47-3Relevant academic research and scientific papers
Synthesis of SHIP1-activating analogs of the sponge meroterpenoid pelorol
Meimetis, Labros G.,Nodwell, Matt,Yang, Lu,Wang, Xiaoxia,Patrick, Brian O.,Andersen, Raymond J.,Wu, Joyce,Harwig, Curtis,Stenton, Grant R.,MacKenzie, Lloyd F.,MacRury, Thomas,Ming-Lum, Andrew,Ong, Christopher J.,Mui, Alice L. -F.,Krystal, Gerald
, p. 5195 - 5207,13 (2020/08/31)
Two biomimetic approaches have been used to synthesize analogs of the SHIP1-activating sponge meroterpenoid pelorol (1). One approach started from the chiral pool plant natural product sclareolide, which has the same absolute configuration as pelorol. The
Total Synthesis of (+)-9,10-syn- and (+)-9,10-anti-Copalol via Epoxy Trienylsilane Cyclizations
Yee, Nathan K. N.,Coates, Robert M.
, p. 4598 - 4608 (2007/10/02)
Total syntheses of (+)-9,10-syn-copalol (5), the pyrophosphate ester of which is a likely intermediate in the biosynthesis of 9,10-syn diterpenes, and its 9,10-anti isomer 39 are reported.Lithiation of (-)-(6R)-6,7-epoxygeranyl p-tolylsulfone (-)-19 or (+
