1428-92-8

Usage

Synonyms

4-BCP, nitrogen mustard analogue

Chemical class

Alkylating agent

Structure

Piperazine derivative with two chloroethyl groups

Function

Used in the synthesis of antineoplastic agents

Target

Cross-links DNA, leading to cell death

Potential treatments

Various cancers, including lymphoma and leukemia

Mechanism of action

Inhibits cell growth and induces apoptosis in cancer cells

Toxicity

Highly toxic

Safety precautions

Handle and use with caution in laboratory and medical settings

Adverse effects

Can cause serious side effects due to its toxicity

Upstream product

• 122-96-3 1,4-bis(2-hydroxyethyl)piperazine 

Downstream Products

• 10586-98-8 1,4-bis-(2-dimethylamino-ethyl)-piperazine 
• 114909-63-6 2-(4-chloro-phenyl)-butyric acid 2,2'-piperazine-1,4-diyl-diethyl ester 
• 109495-32-1 1,4-bis-(2-trimethylammonio-ethyl)-piperazine; diiodide 
• 116810-30-1 4-methyl-2-phenyl-pentanoic acid 2,2'-piperazine-1,4-diyl-diethyl ester 
• 116032-02-1 2-phenyl-hexanoic acid 2,2'-piperazine-1,4-diyl-diethyl ester 
• 7077-33-0 1.4-Bis-<2-(2-phenyl-butyryl-oxy)-ethyl>-piperazin 
• 22746-11-8 1,4-bis<2-(1-piperidino)ethyl>piperazine 

Relevant academic research and scientific papers

Design and Synthesis of RNA-Specific Groove-Binding Cations: Implications for Antiviral Drug Design

As as initial step in the design of structure-specific RNA-interactive molecules as potential antiviral agents, we have focused on the synthesis of molecules that exhibit strong and preferential binding to douplex RNA.A series of polycationic ligands have

Amine ethylated piperazine and preparation method thereof

The invention provides a preparation method of an amine ethylated piperazine, and relates to the technical field of preparation of aminoethyl piperazine. The method comprises the following steps: mixing a piperazine compound, a chlorination reagent and a soluble piperazine compound solvent to carry out chlorination reaction to obtain the chloropiperazine hydrochloride. The piperazine compound comprises 2 - hydroxyethyl piperazine or N, N' - bis (2 - hydroxyethyl) piperazine. The chloropiperazine hydrochloride, the organic amine and the water are mixed, and the substitution reaction is carried out to obtain the aminated piperazine. The organic amine includes methylamine. Diethylamine, propylamine. The preparation method provided by the invention is high in product yield, high in purity, simple to operate, wide in reaction raw material source, low in production cost and suitable for industrial production.