Design and Synthesis of RNA-Specific Groove-Binding Cations: Implications for Antiviral Drug Design

Article abstract of DOI:10.1021/jm00034a004

As as initial step in the design of structure-specific RNA-interactive molecules as potential antiviral agents, we have focused on the synthesis of molecules that exhibit strong and preferential binding to douplex RNA.A series of polycationic ligands have