142809-82-3

Basic information

• Product Name: 4-trifluoroacetyl-3-trifluoromethyl-1-phenylpyrazole
• Synonyms: 4-trifluoroacetyl-3-trifluoromethyl-1-phenylpyrazole
• CAS NO: 142809-82-3
• Molecular Weight: 308.183
• Mol File: 142809-82-3.mol

Chemical Properties

• CAS DataBase Reference: 4-trifluoroacetyl-3-trifluoromethyl-1-phenylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-trifluoroacetyl-3-trifluoromethyl-1-phenylpyrazole(142809-82-3)
• EPA Substance Registry System: 4-trifluoroacetyl-3-trifluoromethyl-1-phenylpyrazole(142809-82-3)

Safety Data

• Hazardous Substances Data: 142809-82-3(Hazardous Substances Data)

Upstream product

• 588-64-7 benzaldehyde phenylhydrazone 
• 142503-30-8 4-Ethylthio-1,1,1-trifluoro-3-(trifluoroacetyl)-3-buten-2-one 
• 100-63-0 phenylhydrazine 
• 142503-29-5 3-dimethylaminomethylene-1,1,1,5,5,5-hexafluoropentane-2,4-dione 
• 74888-65-6 N,N-diethylaminomethylene-1,1,1,5,5,5-hexafluoroacetylacetone 
• 142818-05-1 benzaldehyde N-<β,β-bis(trifluoroacetyl)vinyl>phenylhydrazone 

Downstream Products

• 142818-01-7 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Synthesis of some fluorinated nitrogen heterocycles from (diethylaminomethylene) hexafluoroacetylacetone (DAMFA)

Simple and highly efficient syntheses of the title compounds from DAMFA are described in the quinoline, azepinonaphtalene, azaphenanthrene(s), pyridopyridine, pyrazole, pyrrole and pyrimidine series.

FACILE SYNTHETIC METHODS FOR 3- AND 5-TRIFLUOROMETHYL-4-TRIFLUOROACETYLPYRAZOLES AND THEIR CONVERSION INTO PYRAZOLE-4-CARBOXYLIC ACIDS

3- and 5-Trifluoromethyl-4-trifluoroacetylpyrazoles (4 and 5) were easily synthesized in excellent yields by reaction of β,β-bis(trifluoroacetyl)vinyl ethers 1, sulfides 2, and -amines 3 with hydrazines.Hydrolysis of these compounds (4 and 5) with aqueous potassium hydroxide gave the corresponding pyrazole-4-carboxylic acids (6 and 7) in high yields.