142809-85-6Relevant academic research and scientific papers
FACILE SYNTHETIC METHODS FOR 3- AND 5-TRIFLUOROMETHYL-4-TRIFLUOROACETYLPYRAZOLES AND THEIR CONVERSION INTO PYRAZOLE-4-CARBOXYLIC ACIDS
Okada, Etsuji,Masuda, Ryoichi,Hojo, Masaru
, p. 791 - 798 (2007/10/02)
3- and 5-Trifluoromethyl-4-trifluoroacetylpyrazoles (4 and 5) were easily synthesized in excellent yields by reaction of β,β-bis(trifluoroacetyl)vinyl ethers 1, sulfides 2, and -amines 3 with hydrazines.Hydrolysis of these compounds (4 and 5) with aqueous potassium hydroxide gave the corresponding pyrazole-4-carboxylic acids (6 and 7) in high yields.
