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1428095-61-7

methyl O-benzyl-N-(3α-hydroxy-5β-cholan-24-oyl)-D-serinate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1428095-61-7 Structure

  • Basic information

    1. Product Name: methyl O-benzyl-N-(3α-hydroxy-5β-cholan-24-oyl)-D-serinate
    2. Synonyms: methyl O-benzyl-N-(3α-hydroxy-5β-cholan-24-oyl)-D-serinate
    3. CAS NO:1428095-61-7
    4. Molecular Formula:
    5. Molecular Weight: 581.793
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1428095-61-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl O-benzyl-N-(3α-hydroxy-5β-cholan-24-oyl)-D-serinate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl O-benzyl-N-(3α-hydroxy-5β-cholan-24-oyl)-D-serinate(1428095-61-7)
    11. EPA Substance Registry System: methyl O-benzyl-N-(3α-hydroxy-5β-cholan-24-oyl)-D-serinate(1428095-61-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1428095-61-7(Hazardous Substances Data)

1428095-61-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1428095-61-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,8,0,9 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1428095-61:
(9*1)+(8*4)+(7*2)+(6*8)+(5*0)+(4*9)+(3*5)+(2*6)+(1*1)=167
167 % 10 = 7
So 1428095-61-7 is a valid CAS Registry Number.

1428095-61-7Downstream Products

1428095-61-7Relevant articles and documents

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor

Incerti, Matteo,Tognolini, Massimiliano,Russo, Simonetta,Pala, Daniele,Giorgio, Carmine,Hassan-Mohamed, Iftiin,Noberini, Roberta,Pasquale, Elena B.,Vicini, Paola,Piersanti, Silvia,Rivara, Silvia,Barocelli, Elisabetta,Mor, Marco,Lodola, Alessio

, p. 2936 - 2947 (2013/05/22)

The Eph receptor-ephrin system is an emerging target for the development of novel antiangiogenetic agents. We recently identified lithocholic acid (LCA) as a small molecule able to block EphA2-dependent signals in cancer cells, suggesting that its (5β)-cholan-24-oic acid scaffold can be used as a template to design a new generation of improved EphA2 antagonists. Here, we report the design and synthesis of an extended set of LCA derivatives obtained by conjugation of its carboxyl group with different α-amino acids. Structure-activity relationships indicate that the presence of a lipophilic amino acid side chain is fundamental to achieve good potencies. The l-Trp derivative (20, PCM126) was the most potent antagonist of the series disrupting EphA2-ephrinA1 interaction and blocking EphA2 phosphorylation in prostate cancer cells at low μM concentrations, thus being significantly more potent than LCA. Compound 20 is among the most potent small-molecule antagonists of the EphA2 receptor.

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