1428155-25-2

Basic information

• Product Name: N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide
• Synonyms: N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide
• CAS NO: 1428155-25-2
• Molecular Weight: 593.54
• Mol File: 1428155-25-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide(1428155-25-2)
• EPA Substance Registry System: N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide(1428155-25-2)

Safety Data

• Hazardous Substances Data: 1428155-25-2(Hazardous Substances Data)

Upstream product

• 369-35-7 2-fluoro-4-nitroaniline 
• 1428155-02-5 N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine 
• 1272758-11-8 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid 
• 1428155-04-7 2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine 
• 1428154-99-7 methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate 
• 10128-91-3 methyl 2-hydroxynicotinate 
• 28369-76-8 2-hydroxynicotinic acid chloride 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 7306-68-5 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 

Downstream Products

• 1428155-43-4 C₂₄H₁₅F₄N₇O₂ 

Relevant articles and documents

Inhibitors of the TAM subfamily of tyrosine kinases: Synthesis and biological evaluation

The TAM subfamily of Receptor Tyrosine Kinases (RTKs) contains three human proteins of therapeutical interest, Axl, Mer, and Tyro3. Our goal was to design a type II inhibitor specific for this family, i.e. able to interact with the allosteric pocket and with the hinge region of the kinase. We report the synthesis of several series of purine analogues of BMS-777607. The structural diversity of the designed inhibitors was expected to modify the interactions formed in the binding site and consequently to modulate their selectivity profiles. The most potent inhibitor 6g exhibits Kds of 39, 42, 65 and 200 nM against Axl, Mer, Met and Tyro3 respectively. Analysis of the affinity of 6g for active and inactive forms of Abl1, an RTK protein that does not belong to the TAM subfamily, together with the binding modes of 6g predicted by docking studies, indicates that 6g displays some selectivity for the TAM family and may act as a type II inhibitor. Crown Copyright