142818-80-2

Upstream product

• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 90-02-8 salicylaldehyde 
• 1846-91-9 2-oxo-2H-chromene-3-carbohydrazide 
• 1846-76-0 ethyl coumarin-3-carboxylate 
• 89-95-2 2-methyl-benzyl alcohol 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 944246-14-4 [Co(NO₃)2(2-(chromen-2'-onyl)-5-(4''-nitrophenyl)1,3,4-oxadiazole)2] 
• 944246-16-6 [Co(ClO₄)2(2-(chromen-2'-onyl)-5-(4''-nitrophenyl)1,3,4-oxadiazole)2] 
• 944246-12-2 [CoBr₂(2-(chromen-2'-onyl)-5-(4''-nitrophenyl)1,3,4-oxadiazole)2] 
• 944246-10-0 [CoCl₂(2-(chromen-2'-onyl)-5-(4''-nitrophenyl)1,3,4-oxadiazole)2] 
• 944246-18-8 [Co(CH₃COO)2(2-(chromen-2'-onyl)-5-(4''-nitrophenyl)1,3,4-oxadiazole)2] 

Relevant academic research and scientific papers

Synthesis of 3-(5-phenyl-1, 3,4-oxadiazol-2-yl)-2H-chromen-2-ones as anticonvulsant agents

3-(5-Phenyl-l,3,4-oxadiazol-2-yl)-2H-chromen-2-one (IVa-IVl) have been synthesized from N-benzylidene2-oxo-2#- chromene-3-carbohydrazide (IIIa-IIIl). The structure of synthesized coumarinyl oxadiazoles have been established by spectral data, elemental ana

Synthesis, spectral characterization and biocidal studies of copper(II) complexes of chromen- 2-one-3-carboxy hydrazide and 2-(Chromen-3'-onyl)- 5-(aryl)-1,3,4-oxadiazole derivatives

Copper(II) complexes of chromen-2-one-3-carboxyhydrazide and 2-(chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole derivatives have been synthesized. The structural features have been determined from their microanalytical, magnetic susceptibility, molar conductance, IR, UV Vis, 1H NMR and ESR spectral data. All the Cu(II) complexes exhibit the composition Cu(Ln) 2X2; where L1= chromen-2-one-3-carboxy hydrazide, L2 = 2-(chromen-3'-onyl)- 5-(2"-hydroxy phenyl)-1,3,4-oxadiazole, L3 = 2-(chromen-3'-onyl)-5-(4"- nitrophenyl)-1,3,4 -oxadiazole and L4 = 2-(chromen-3'-onyl)-5-(4"- chlorophenyl)-1,3,4-oxadiazole; X = Cl-, Br-, NO3 -, CH3COO-, ClO4 - and CNS-. The N, O donor ligands act as a bidentate ligand in all the complexes. Distorted octahedral geometry for all the Cu(II) complexes is proposed. Molecular modeling studies have been made for the rapid structure building, geometry optimization and molecular display. These complexes show the conductance values, supporting their non-electrolytic nature. The monomeric nature of the complexes was confirmed from their magnetic susceptibility values. These complexes have been screened for their antimicrobial activities against some bacterial species like S.aureus, E.coli, Pseudomonas aeruginosa and few fungal strains C.albicans and Cryptococcus neoformans.

Synthesis and characterization of cobalt (II) complexes of chromen-2-one-3-carboxy hydrazide and 2-(chromen-2′-onyl)-5-(aryl) 1,3,4-oxadiazole derivatives

Cobalt(II) complexes of chromen-2-one-3-carboxy hydrazide and 2-(chromen 2′-onyl)-5-(aryl)-1,3,4-oxadiazole derivatives have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, spectral studies [IR, UV-vis, and 1H NMR]. All the Co(II) complexes exhibit the composition M(Ln)2X2; where M = Co(II), L1 is chromen-2-one-3-carboxy hydrazide, L2 is 2-(chromen-2′-onyl)-5-(2″- hydroxylphenyl)1,3,4-oxadiazole, L3 2-(chromen-2′-onyl)-5-(4″- nitrophenyl)1,3,4-oxadiazole and L4 is 2-(chromen-2′-onyl)-5-(4″- chlorophenyl)1,3,4-oxadiazole. X = Cl-, Br-, NO 3-, CH3COO- , ClO4 -, CNS-, SO4-. The N,O donor ligands act as a bidentate ligand in all the complexes. Distorted octahedral geometry for all the Co(II) complexes is proposed. X-ray structure determination has been made for the exact definition of the coordination sphere. The newly synthesized Co(II) complexes have been screened for their antimicrobial activity against some bacterial species like E. coli, S. aureus, Pseudomonas aeruginosa and few fungal strains, C. albicans and Cryptococcus neoformans.

Microwave accelerated solvent-free synthesis of 1,3,4-oxadiazoles using polymer supported dehydration reagent

2-Aryl-5-(coumarin-3′-yl)-1,3,4-oxadiazoles are efficiently synthesized by microwave accelerated solvent-free procedure in high yield via the condensation of coumarin-3-carboxylic acid with (un)substituted benzoic acid hydrazides using poly(ethylene glyco

Synthesis of some new 2, 5-disubstituted 1,3,4-oxadiazole derivatives and their biological activity

2-(Coumarin-3-yl)-5-aryl-1,3,4-oxadiazole derivatives 3-5 have been synthesised by condensing hydrazide 2 of 3-carbethoxycoumarin with various aromatic acids. Compound 3 is also synthesized by another route involving synthesis of an intermediate N-2-hydroxy benzylidene coumarin-3-carboxyhydrazide 6 which is prepared by reacting 2 with salicylaldehyde. On refluxing it in presence of chloramine T the desired 1,3,4- oxadiazole derivative 3 is obtained. In another set of experiments, 4-methyl-7-(5-phenyl-1,3,4-oxadiazole-2-yl methoxy) coumarin 10 and 4-methyl-7-(5-amino-1,3,4-oxadiazo-2-yl methoxy) coumarin 11 were prepared by condensing 4-methyl coumarinyl-7-oxyacetic hydrazide 9 with benzoic acid and cyanogen bromide respectively. All the oxadiazole derivatives and the compound 6 have been tested for their antiinflammatory, analgesic and antimicrobial activity with interesting results.