1428183-50-9

Basic information

• Product Name: C₂₁H₂₁ClN₂O₃
• Synonyms: C₂₁H₂₁ClN₂O₃
• CAS NO: 1428183-50-9
• Molecular Weight: 384.862
• Mol File: 1428183-50-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁ClN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁ClN₂O₃(1428183-50-9)
• EPA Substance Registry System: C₂₁H₂₁ClN₂O₃(1428183-50-9)

Safety Data

• Hazardous Substances Data: 1428183-50-9(Hazardous Substances Data)

Upstream product

• 65713-63-5 ethyl 5-methyl-3-oxo-1,2-dihydropyrrole-4-carboxylate 
• 20461-26-1 1-(4-chlorophenyl)-2, 5-dimethyl-1H-pyrrole-3-carbaldehyde 
• 110-13-4 2,5-hexanedione 
• 626-34-6 ethyl aminocrotonate 
• 5044-23-5 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole 
• 78120-39-5 (E)-ethyl 3-amino-2-(2-chloroacetyl)but-2-enoate 

Relevant articles and documents

Discovery and structure-activity relationships of pyrrolone antimalarials

In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 ～ 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways in which the molecule could be optimized. This compound represents an exciting start point for a drug discovery program for the development of a novel antimalarial.