142820-81-3Relevant academic research and scientific papers
Synthesis of 3′-acetamidoadenosine derivatives as potential A 3 adenosine receptor agonists
Chun, Moon Woo,Choi, Sung Wook,Kang, Tae Kyung,Choi, Won Jun,Kim, Hea Ok,Gao, Zhan-Guo,Jacobson, Kenneth A.,Jeong, Lak Shin
, p. 408 - 420 (2008/09/19)
On the basis of high binding affinity of 3′-aminoadenosine derivatives 2b at the human A3 adenosine receptor (AR), 3′- acetamidoadenosine derivatives 3a-e were synthesized from 1,2:5,6-di-O- isopropylidene-D-glucose via stereoselective hydroboration as a key step. Although all synthesized compounds were totally devoid of binding affinity at the human A3AR, our results revealed that 3′-position of adenosine can only be tolerated with small size of a hydrogen bonding donor like hydroxyl or amino group in the binding site of human A3AR. Copyright Taylor & Francis Group, LLC.
