1428245-15-1

Basic information

• Product Name: C₁₃H₆⁽²⁾H₄O₂
• CAS NO: 1428245-15-1
• Molecular Weight: 202.189
• Mol File: 1428245-15-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₃H₆⁽²⁾H₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₆⁽²⁾H₄O₂(1428245-15-1)
• EPA Substance Registry System: C₁₃H₆⁽²⁾H₄O₂(1428245-15-1)

Safety Data

• Hazardous Substances Data: 1428245-15-1(Hazardous Substances Data)

Upstream product

• 4165-57-5 bromobenzene-d5 
• 100-52-7 benzaldehyde 
• 95450-78-5 pentadeuterophenyl-phenyl-methanol 
• 2694-78-2 2,3,4,5,6-Pentadeuteriobenzophenon 
• 611-73-4 Benzoylformic acid 

Relevant articles and documents

RhIII-Catalyzed Decarboxylative o-Acylation of Arenes Bearing an Oxidizing Directing Group

Here in we report, rhodium(III)-catalyzed decarboxylative acylation of arenes using α-oxocarboxylic acids as acyl surrogate. In this strategy, O–NHAc group act as an autocleavable oxidizing directing group (ODGauto), thus giving rise to ortho-acylated phenols in moderate to good yields. Mechanistic studies provided strong support for a kinetically relevant C–H bond activation. According to the best of our knowledge, this is the first report of Rhodium catalyzed decarboxylative acylation.

Synthesis of ortho-acylphenols through the palladium-catalyzed ketone-directed hydroxylation of arenes

ortho-Acylphenols are an important structural motif found in a diversity of bioactive molecules ranging from natural products to drugs (Figure 1). Moreover, they also serve as versatile building blocks for the synthesis of various pharmaceuticals, such as warfarin, as well as agrichemicals, flavors, and fragrances. Classic approaches to the synthesis of o-acylphenols generally involve a two-step process: acylation of phenols followed by Fries rearrangement of the resulting phenyl esters (Scheme 1a). On the other hand, direct C-acylation of phenols has also been known under more forcing conditions. Although effective, these approaches are often complicated by the formation of undesired p-substituted products when bulky acyl groups need to be introduced, as well as the limited variety of ketones that can be generated.