1428250-75-2Relevant academic research and scientific papers
A facile synthesis of 3,5,7-trisubstituted-4H-[1,2]diazepines by microwave irradiation
Manih, Rudolf Manton,Myrboh, Bekington
, p. 1613 - 1618 (2013/01/15)
A novel approach for the synthesis of 3,5,7-trisubstituted-4H-[1,2] diazepine 5a-p from α,β-unsaturated 1,5-diketone 4 by the condensation of substituted acetophenones 1 with 1,3-dicarbonyl compound 3 in the presence of sodium tertiary butoxide has been described. The intermediate 4 reacts smoothly with hydrazine hydrate catalysed by PSSA in water under microwave irradiation to yield the product 5.
