1428259-26-0Relevant articles and documents
Synthesis, characterization, and cytotoxic activity of N-metallated rhenium(I) pincer complexes with (thio)phosphoryl pendant arms
Aleksanyan, Diana V.,Brunova, Valentina V.,Churusova, Svetlana G.,Denisov, Gleb L.,Klemenkova, Zinaida S.,Kozlov, Vladimir A.,Peregudov, Alexander S.,Rybalkina, Ekaterina Yu.,Susova, Olga Yu.
, (2020)
ortho-Phosphorylated aniline and its thio analog were used as key precursors for the synthesis of new multidentate ligands based on functionalized monothiooxamides. These compounds readily formed pincer-type complexes in reactions with Re(CO)5Br upon addition of a base. The realization of a tridentate monoanionic coordination of the functionalized monothiooxamide ligands in the resulting complexes through the oxygen or sulfur atom of the ancillary P=X donor group, the nitrogen atom of the deprotonated amide unit, and the sulfur atom of the thioamide moiety was unambiguously confirmed by the multinuclear NMR and IR spectroscopic data as well as X-ray diffraction. Investigation of the cytotoxic properties of these complexes against several human cancer cell lines revealed the high potential of the P(O)-substituted derivative. For comparison, the related complex with the more flexible phosphoryl pendant arm was prepared in an analogous manner and tested for cytotoxic activity. Although this compound also demonstrated remarkable cytotoxic effects on the cancer cell lines explored, it was slightly inferior to its analog with the more rigid phosphorus(V) coordination arm. The cytotoxic properties of the rhenium complexes were shown to be associated mainly with the coordination by Re(I) ions, since the free monothiooxamide ligands almost do not inhibit or even stimulate proliferation of the cancer cells. All this renders the creation of new potential anticancer agents based on Re(I) pincer complexes of functionalized ortho-phosphorylanilides very promising.
Functionalized mercaptoacetic and propionic acid amides: synthesis, cyclopalladation features, and catalytic activity of metal complexes
Churusova,Aleksanyan,Klemenkova,Nelyubina, Yu. V.,Artyushin,Vasil’ev,Kozlov,Sudarikov,Rubtsova
, p. 2678 - 2689 (2015)
Upon treatment with thiophenol or neomenthyl mercaptane, chloroacetand propionamides with an additional Nor S-donor substituent in the amine part gave new multidentate ligands readily undergoing direct cyclopalladation in the reaction with PdCl2/sub
Coordination of P(X)-modified (X = O, S) N-aryl-carbamoylmethylphosphine oxides and sulfides with Pd(II) and Re(I) ions: Facile formation of 6,6-membered pincer complexes featuring atropisomerism
Aleksenko,Sharova,Artyushin,Aleksanyan,Klemenkova,Nelyubina,Petrovskii,Kozlov,Odinets
, p. 168 - 179 (2013/04/10)
Direct acetylation of (thio)phosphorylated anilines 1a,b with in situ generated Ph2P(O)CH2C(O)Cl or sequential treatment of 1a,b with chloroacetyl chloride and Ph2PSNa resulted in novel oligodentate ligands, namely, P(X)-m
