142826-92-4Relevant academic research and scientific papers
Synthesis of N-phenyl β-amino acids via iridium-catalyzed asymmetric hydrogenation using mixed monodentate ligands
Mrsic, Natasa,Panella, Lavinia,Minnaard, Adriaan J.,Feringa, Ben L.,De Vries, Johannes G.
, p. 36 - 39 (2011)
The iridium-catalyzed asymmetric hydrogenation of N-phenyl-β- dehydroamino acid derivatives was examined using monodentate phosphoramidite ligands. The highest yields and enantioselectivities were obtained using a mixed ligand approach with PipPhos L1 and
Tetrahydroquinoline derivatives as CRTH2 antagonists
Liu, Jiwen,Wang, Yingcai,Sun, Ying,Marshall, Derek,Miao, Shichang,Tonn, George,Anders, Penny,Tocker, Joel,Tang, H. Lucy,Medina, Julio
scheme or table, p. 6840 - 6844 (2010/05/19)
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 an
Production method for optically active N-aryl-beta-amino acid compounds
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Page 8, (2010/02/08)
In a method suitable for industrial application, an optically active N-aryl-β-amino acid compound is produced by the reaction of an aromatic amine and an optically active sulfonylated β-hydroxycarboxylic acid compound. The latter can be easily derived from a β-keto carboxylic acid compound.
Amine-salt-controlled, catalytic asymmetric conjugate addition of various amines and asymmetric protonation
Hamashima, Yoshitaka,Somei, Hidenori,Shimura, Yuta,Tamura, Toshihiro,Sodeoka, Mikiko
, p. 1861 - 1864 (2007/10/03)
Matrix presented. The combined use of chiral Pd complex 2 and amine salt enabled completely regulated release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric conjugate addition of various amines was achieved to afford
Pd/Cu-catalyzed couplings of β-amino esters with aryl bromides. Synthesis of chiral 1,2,3,4-tetrahydro-4-oxo-2-alkyl-1-quinolines
Ma, Dawei,Jiang, Jiqing
, p. 1137 - 1142 (2007/10/03)
A new protocol to prepare chiral 1,2,3,4-tetrahydro-4-oxo-2-alkyl-l- quinolines has been developed. The key steps are Pd/Cu-catalyzed couplings of chiral β-amino esters and aryl bromides, and intramolecular acylation.
