142826-92-4Relevant academic research and scientific papers
Synthesis of N-phenyl β-amino acids via iridium-catalyzed asymmetric hydrogenation using mixed monodentate ligands
Mrsic, Natasa,Panella, Lavinia,Minnaard, Adriaan J.,Feringa, Ben L.,De Vries, Johannes G.
, p. 36 - 39 (2011)
The iridium-catalyzed asymmetric hydrogenation of N-phenyl-β- dehydroamino acid derivatives was examined using monodentate phosphoramidite ligands. The highest yields and enantioselectivities were obtained using a mixed ligand approach with PipPhos L1 and
Tetrahydroquinoline derivatives as CRTH2 antagonists
Liu, Jiwen,Wang, Yingcai,Sun, Ying,Marshall, Derek,Miao, Shichang,Tonn, George,Anders, Penny,Tocker, Joel,Tang, H. Lucy,Medina, Julio
scheme or table, p. 6840 - 6844 (2010/05/19)
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 an
Amine-salt-controlled, catalytic asymmetric conjugate addition of various amines and asymmetric protonation
Hamashima, Yoshitaka,Somei, Hidenori,Shimura, Yuta,Tamura, Toshihiro,Sodeoka, Mikiko
, p. 1861 - 1864 (2007/10/03)
Matrix presented. The combined use of chiral Pd complex 2 and amine salt enabled completely regulated release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric conjugate addition of various amines was achieved to afford
Production method for optically active N-aryl-beta-amino acid compounds
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Page 8, (2010/02/08)
In a method suitable for industrial application, an optically active N-aryl-β-amino acid compound is produced by the reaction of an aromatic amine and an optically active sulfonylated β-hydroxycarboxylic acid compound. The latter can be easily derived from a β-keto carboxylic acid compound.
Pd/Cu-catalyzed couplings of β-amino esters with aryl bromides. Synthesis of chiral 1,2,3,4-tetrahydro-4-oxo-2-alkyl-1-quinolines
Ma, Dawei,Jiang, Jiqing
, p. 1137 - 1142 (2007/10/03)
A new protocol to prepare chiral 1,2,3,4-tetrahydro-4-oxo-2-alkyl-l- quinolines has been developed. The key steps are Pd/Cu-catalyzed couplings of chiral β-amino esters and aryl bromides, and intramolecular acylation.
