1428263-22-2

Upstream product

• 1428263-21-1 N-(2-iodophenyl)-N-[(2E)-1-methylbut-2-en-1-yl]amine 
• 79-04-9 chloroacetyl chloride 
• 615-43-0 2-iodophenylamine 
• 18610-33-8 (E)-4-chloropent-2-ene 

Downstream Products

• 1428263-24-4 2-chloro-N-(2-iodophenyl)-N-(1-methyl-2-oxoethyl)acetamide 

Relevant academic research and scientific papers

Synthesis and reactions of N-acetyl- and N-(2-chloroacetyl)-N-[(2E)-1- methylbut-2-en-1-yl]-2-iodoanilines

The reaction of N-(1-methylbut-2-en-1-yl)-2-iodaniline with Ac2O or ClCH2C(O)Cl results in a mixture of syn- and anti-atropisomers of N-acetyl- and N-chloroacetyl-N-(1-methylbut-2-en-1-yl)-2-iodaniline in a ratio of 1:1. Ozonolysis of the latter followed by reduction with dimethyl sulfide in CH2Cl2 gives rise to the atropisomers mixture of 2-[N-(chloroacetyl)-N-(2-iodophenyl)]aminopropanal in a ratio of 1:3. When heated in boiling benzene, the mixture of atropoisomeric aldehydes reacts with triphenylphosphine to afford a mixture of 2-[(N-acetyl)-N-(2-iodophenyl)] aminopropanal atropisomers in 1:3 ratio.