1428331-74-1Relevant academic research and scientific papers
Silver-Catalyzed Decarboxylative Alkylfluorination of Alkenes
Li, Chen-Guang,Xie, Qiang,Xu, Xiao-Lan,Wang, Feng,Huang, Bei,Liang, Yu-Feng,Xu, Hua-Jian
, p. 8496 - 8500 (2019)
A decarboxylation of alkyl carboxylic acids for alkylfluorination of alkene was developed, with the catalysis of silver(I) and Selectfluor as both the oxidant and fluorine source. This reaction is highly chemoselective, producing the decarboxylative alkyl
Iron(II)-catalyzed benzylic fluorination
Bloom, Steven,Pitts, Cody Ross,Woltornist, Ryan,Griswold, Andrew,Holl, Maxwell Gargiulo,Lectka, Thomas
supporting information, p. 1722 - 1724 (2013/06/26)
Direct C-F functionalization of benzylic sp3 C-H bonds is a synthetic challenge that has yet to be propitiously overcome. A mild, one-pot synthesis of monofluorinated benzylic substrates is reported with commercially available iron(II) acetylacetonate and Selectfluor in good to excellent yields and selectivity. A convenient route to β-fluorinated products of 3-aryl ketones is also highlighted, providing a synthetic equivalent to the difficult to accomplish conjugate addition of fluoride to α,β-unsaturated ketones.
