1428332-99-3

Upstream product

• 136918-14-4 phthalimide 
• 22546-83-4 N-hydroxymethyl-3-nitrophthalimide 
• 54455-37-7 2-chloromethyl-5-nitro-isoindole-1,3-dione 
• 1428332-97-1 C₂₀H₂₀N₄O₄ 

Downstream Products

• 1428333-01-0 C₂₇H₂₈N₄O₄S 
• 1428333-02-1 C₂₀H₂₂N₄O₄S 

Relevant academic research and scientific papers

A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues as α-glucosidase inhibitors

Several members of a new family of non-sugar-type α-glycosidase inhibitors, bearing a 5-(p-toluenesulfonylamino)phthalimide moiety and various substituent at the N2 position, were synthesized and their activities were investigated. The newly synthesized compounds displayed different inhibition profile towards yeast α-glycosidase and rat intestinal α-glycosidase. Almost all the compounds had strong inhibitory activities against yeast α-glycosidase. Regarding rat intestinal α-glycosidase, only analogs with N2-aromatic substituents displayed varying degrees of inhibitory activities on rat intestinal maltase and lactase and nearly all compounds showed no inhibition against rat intestinal α-amylase. Structure-activity relationship studies indicated that 5-(p- toluenesulfonylamino)phthalimide moiety is a favorable scaffold to exert the α-glucosidase inhibitory activity and substituents at the N2 position have considerable influence on the efficacy of the inhibition activities.