54455-37-7 Usage
Uses
Used in Pharmaceutical Synthesis:
2-(chloromethyl)-5-nitro-isoindole-1,3-dione serves as an intermediate in the synthesis of a variety of pharmaceuticals. Its unique structure makes it a valuable component in the development of cardioactive compounds, which are essential for treating heart-related conditions, and drugs aimed at addressing neurological disorders, where its potential therapeutic effects are being explored.
Used in Cancer Research and Treatment:
2-(chloromethyl)-5-nitro-isoindole-1,3-dione has garnered interest in the field of oncology due to its potential as an anti-cancer agent. The exploration of its anti-cancer properties involves studying how it may interact with biological systems to inhibit or kill cancer cells, offering a new avenue for cancer treatment.
Used in Organic Chemistry as a Building Block:
The presence of the chloromethyl group in 2-(chloromethyl)-5-nitro-isoindole-1,3-dione makes it a versatile building block in organic chemistry. Its ability to undergo nucleophilic substitution reactions allows chemists to use it as a starting material for the synthesis of a wide range of complex organic molecules, which can be tailored for specific applications in various industries, including materials science, pharmaceuticals, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 54455-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,4,5 and 5 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 54455-37:
(7*5)+(6*4)+(5*4)+(4*5)+(3*5)+(2*3)+(1*7)=127
127 % 10 = 7
So 54455-37-7 is a valid CAS Registry Number.
54455-37-7Relevant academic research and scientific papers
A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues as α-glucosidase inhibitors
Bian, Xiaoli,Wang, Qian,Ke, Changhu,Zhao, Guilan,Li, Yiping
, p. 2022 - 2026 (2013/04/24)
Several members of a new family of non-sugar-type α-glycosidase inhibitors, bearing a 5-(p-toluenesulfonylamino)phthalimide moiety and various substituent at the N2 position, were synthesized and their activities were investigated. The newly synthesized compounds displayed different inhibition profile towards yeast α-glycosidase and rat intestinal α-glycosidase. Almost all the compounds had strong inhibitory activities against yeast α-glycosidase. Regarding rat intestinal α-glycosidase, only analogs with N2-aromatic substituents displayed varying degrees of inhibitory activities on rat intestinal maltase and lactase and nearly all compounds showed no inhibition against rat intestinal α-amylase. Structure-activity relationship studies indicated that 5-(p- toluenesulfonylamino)phthalimide moiety is a favorable scaffold to exert the α-glucosidase inhibitory activity and substituents at the N2 position have considerable influence on the efficacy of the inhibition activities.
