1428339-80-3Relevant academic research and scientific papers
Crystallization-induced dynamic resolution of fox chiral auxiliary and application to the diastereoselective electrophilic fluorination of amide enolates
Lubin, Hodney,Dupuis, Christophe,Pytkowicz, Julien,Brigaud, Thierry
, p. 3487 - 3492 (2013)
A highly efficient crystallization-induced dynamic resolution (CIDR) of trans-Fox (fluorinated oxazolidine) chiral auxiliary is reported. This chiral auxiliary was used for highly diastereoselective (>98% de) electrophilic fluorination of amide enolates. After removal of the chiral auxiliary, highly valuable enantiopure α-fluorocarboxylic acids and β-fluoroalcohols are obtained.
