(2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Base Information

Chemical Name:(2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine
CAS No.:1428339-80-3
Molecular Formula:C₂₇H₂₆F₄N₂O₂
Molecular Weight:486.509
Hs Code.:

Synonyms:(2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

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Technology Process of (2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

There total 1 articles about (2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1026021-04-4
(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine

: 1428339-80-3
(2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -70 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo400210j

Reference yield:

: 1428339-80-3
(2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: C₂₇H₂₈F₄N₂O₂

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo400210j

Reference yield:

: 1428339-80-3
(2S,4R)-3-[(2R)-3-dibenzylamino-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: 1428339-73-4
(2S,4R)-4-phenyl-3-phenylacetyl-2-trifluoromethyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 2 h / -10 °C / Inert atmosphere

2: acetic acid / chloroform / 2 h

With lithium aluminium tetrahydride; acetic acid; In diethyl ether; chloroform;
DOI:10.1021/jo400210j