142836-69-9

Upstream product

• 100-39-0 benzyl bromide 
• 124638-95-5 1-hydroxyacetyl-1-phthalimidocyclopropane ethylene ketal 

Downstream Products

• 141363-51-1 2-amino-6-benzyloxymethylpteridine-7-spirocyclopropan-4(3H)-one 
• 142836-72-4 2-amino-6-<1-(2-benzyloxy-1-oxoethyl)cyclopropylamino>-5-nitropyrimidin-4(3H)-one 
• 142836-71-3 2-Amino-6-[1-(2-benzyloxymethyl-[1,3]dioxolan-2-yl)-cyclopropylamino]-5-nitro-3H-pyrimidin-4-one 

Relevant academic research and scientific papers

Latent Inhibitors. Part 8. Synthesis and Evaluation of some Mechanism-based Inhibitors of Dihydrofolate Reductase

The synthesis of two new pteridine-7-spirocyclopropanes that are time-dependent irreversible inhibitors of dihydrofolate reductase is described.Several related compounds including a cyclopropyl substituted quinoxaline and 2-aminopteridine-4(3H),6(5H)-dione were also prepared but these compounds were not found to be time-dependent inhibitors.The inhibitors were assessed using several dihydrofolate reductases, Escherichia coli RT/39, two mutants of the E. coli enzyme, Lactobacillus casei, and chicken liver.Activity was found against all enzymes tested but most strongly against E. coli wild type enzyme.