142843-07-0Relevant articles and documents
Inhibitors of Human Renin with C-Termini Derived from Amides and Esters of α-Mercaptoalkanoic Acids
Ashton, Wallace T.,Cantone, Christine L.,Tolman, Richard L.,Greenlee, William J.,Lynch, Robert J.,et al.
, p. 2772 - 2781 (1992)
New transition-state analogues bearing C-termini derived from α-mercaptoalkanoic acids, esters, and amides were prepared and evaluated as inhibitors of human renin.Addition of α-mercaptoalkanoate esters to a chiral Boc-amino epoxide intermediate led ultim
RENIN INHIBITORS CONTAINING THE 2-[[(2R,3S)-3-AMINO-4-CYCLOHEXYL-2-HYDROXY-1-BUTYL]THIO]ALKANOYL MOIETY AND THE CORRESPONDING SULFOXIDE AND SULFONE DERIVATIVES
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, (2008/06/13)
Compounds of the formula: STR1 which are potent inhibitors of human renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory compounds