Inhibitors of Human Renin with C-Termini Derived from Amides and Esters of α-Mercaptoalkanoic Acids

Article abstract of DOI:10.1021/jm00093a009

New transition-state analogues bearing C-termini derived from α-mercaptoalkanoic acids, esters, and amides were prepared and evaluated as inhibitors of human renin.Addition of α-mercaptoalkanoate esters to a chiral Boc-amino epoxide intermediate led ultim