1428535-79-8Relevant academic research and scientific papers
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite
Giannini, Giuseppe,Battistuzzi, Gianfranco,Vignola, Davide
, p. 459 - 461 (2015/01/30)
Recent studies have highlighted a key role in regulating gene transcription, in both eukaryotes and prokaryotes, by enzymes that control the acetylation and deacetylation of histones. In particular, inhibitors of histone deacetylases (HDAC-Is) have been s
ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors
Barbarino, Marcella,Battistuzzi, Gianfranco,Cabri, Walter,Fant, Nicola,Giannini, Giuseppe,Guglielmi, Mario Berardino,Milazzo, Ferdinando M.,Mor, Marco,Pala, Daniele,Pisano, Claudio,Rivara, Silvia,Santaniello, Mos,Taddei, Maurizio,Vesci, Loredana,Vignola, Davide
, p. 8358 - 8377 (2014/12/11)
A systematic study of medicinal chemistry aimed at identifying a new generation of HDAC inhibitors, through the introduction of a thiol zinc-binding group (ZBG) and of an amide-lactam in the ω-position of the polyethylene chain of the vorinostat scaffold,
NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS
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Paragraph 0110; 0120-0124; 0142-0144, (2014/07/23)
The present invention relates to novel amide compounds of Formula (I), and their use as anti-tumoral and pro-apoptotic agents. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an i
NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS
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Page/Page column 18; 19; 21, (2013/04/10)
The present invention relates to novel amide compounds of Formula (I), and their use as anti-tumoral and pro-apoptotic agents. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an i
