1428535-79-8Relevant articles and documents
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite
Giannini, Giuseppe,Battistuzzi, Gianfranco,Vignola, Davide
, p. 459 - 461 (2015/01/30)
Recent studies have highlighted a key role in regulating gene transcription, in both eukaryotes and prokaryotes, by enzymes that control the acetylation and deacetylation of histones. In particular, inhibitors of histone deacetylases (HDAC-Is) have been s
NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS
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Paragraph 0110; 0120-0124; 0142-0144, (2014/07/23)
The present invention relates to novel amide compounds of Formula (I), and their use as anti-tumoral and pro-apoptotic agents. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an i