1428552-13-9Relevant academic research and scientific papers
Simplified synthesis of aryliodonium ylides by a one-pot procedure
Cardinale, Jens,Ermert, Johannes
supporting information, p. 2067 - 2069 (2013/04/23)
A simplified synthesis of iodonium ylides was developed by the one-pot synthesis of phenyliodonium-(5-[2,2-dimethyl-1,3-dioxane-4,6-dione]) ylide as a model system. Such ylides are excellent precursors for nucleophilic no-carrier-added 18F-fluorination of even non-activated arenes. The suitability of the one-pot method is exemplified for several electron rich iodonium ylides. Further, the syntheses of 2-, 3- and 4-bromophenyliodonium-(5- [2,2-dimethyl-1,3-dioxane-4,6-dione]) ylide, and 4-iodophenyliodonium-(5-[2,2- dimethyl-1,3-dioxane-4,6-dione]) ylide, two novel precursors for 4-[ 18F]fluoro-1-halobenzene, are reported.
