1428583-83-8

Basic information

• Product Name: C₂₈H₂₅ClN₄O₅S
• CAS NO: 1428583-83-8
• Molecular Weight: 565.049
• Mol File: 1428583-83-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₅ClN₄O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₅ClN₄O₅S(1428583-83-8)
• EPA Substance Registry System: C₂₈H₂₅ClN₄O₅S(1428583-83-8)

Safety Data

• Hazardous Substances Data: 1428583-83-8(Hazardous Substances Data)

Upstream product

• 2971-79-1 isonipecotic acid methyl ester 
• 120890-66-6 2-chloro-4-fluoro-5-nitrobenzoyl chloride 

Downstream Products

• 1428583-86-1 C₂₇H₂₃ClN₄O₅S 

Relevant articles and documents

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT)

We previously reported the discovery of the activity of chloronitrobenzamides (CNBs) against bloodstream forms of Trypanosoma brucei. Herein we disclose extensive structure-activity relationship and structure-property relationship studies aimed at identification of tractable early leads for clinical development. These studies revealed a promising lead compound, 17b, that exhibited nanomolar potency against T. brucei (EC 50 = 27 nM for T. b. brucei, 7 nM for T. b. rhodesiense, and 2 nM for T. b. gambiense) with excellent selectivity for parasite cells relative to mammalian cell lines (EC50 > 25 μM). In addition compound 17b displayed suitable physiochemical characteristics and microsomal stability (t1/2 > 4 h for human and mouse) to justify pursuing in vivo studies.