1428649-06-2

Upstream product

• 875770-34-6 N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]biotinamide 
• 359860-27-8 N-(2-(2-(2-(2-amidoethoxy)ethoxy)ethoxy)ethoxy)biotinamide 
• 1428649-04-0 9-{4-[4-(tert-butyldiphenylsilyloxy)methyl]benzoylphenyl}-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 1428649-03-9 9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine 
• 1394235-41-6 9-bromo-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine 
• 1428649-02-8 4-[(tert-butyldiphenylsilyloxy)methyl]-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzophenone 
• 1428649-01-7 4-[(tert-butyldiphenylsilyloxy)methyl]-N-methoxy-N-methylbenzamide 
• 1313217-83-2 4-hydroxymethyl-N-methoxy-N-methylbenzamide 
• 3006-96-0 3-hydroxymethyl-benzoic acid 

Relevant academic research and scientific papers

Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182

To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photoaffinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure-activity relationship studies. These probes retained the potent anti-HIV activity of the original pyrimidobenzothiazine derivatives. In photoaffinity labeling studies using HIV-1-infected H9 cells (H9IIIB), eight potential proteins were observed to bind PD 404182.