1428650-48-9

Upstream product

• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 36155-79-0 4-bromo-2-propyl thiophene 
• 1428650-45-6 (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate 
• 1260604-96-3 (R)-2-((tert-butoxycarbonyl)amino)-4-(3,4-dimethoxyphenyl)butanoic acid 
• 1428650-47-8 (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-hydroxybutan-2-yl)carbamate 

Relevant academic research and scientific papers

Divergent asymmetric synthesis of hexahydrobenzophenanthridine dopamine D1 agonists, A-86929, and dihydrexidine

A divergent and scalable asymmetric synthesis of the dopamine D1 agonists, A-86929, and dihydrexidine with high diastereo- and enantioselectivity was accomplished from Weinreb amide 8 derived from inexpensive and easily available l-serine. The synthesis of A-86929 involves only one chromatographic purification.