1428668-40-9

Basic information

• Product Name: methyl 1-(3,3-diphenylpropyl)-2-(2-propyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate
• Synonyms: methyl 1-(3,3-diphenylpropyl)-2-(2-propyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate
• CAS NO: 1428668-40-9
• Molecular Weight: 529.638
• Mol File: 1428668-40-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 1-(3,3-diphenylpropyl)-2-(2-propyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(3,3-diphenylpropyl)-2-(2-propyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate(1428668-40-9)
• EPA Substance Registry System: methyl 1-(3,3-diphenylpropyl)-2-(2-propyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate(1428668-40-9)

Safety Data

• Hazardous Substances Data: 1428668-40-9(Hazardous Substances Data)

Upstream product

• 1428668-32-9 C₃₀H₂₆ClN₃O₂ 
• 141-75-3 butyryl chloride 
• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 445466-24-0 C₂₃H₂₄N₂O₂ 
• 1428668-20-5 C₃₀H₂₆ClN₃O₅ 
• 1428668-26-1 C₃₀H₂₄ClN₃O₄ 

Relevant articles and documents

Multistep divergent synthesis of benzimidazole linked benzoxazole/ benzothiazole via copper catalyzed domino annulation

An efficient, facile synthesis of structurally diverse benzimidazole integrated benzoxazole and benzothiazoles has been developed. In a multi-step synthetic sequence, 4-fluoro-3-nitrobenzoic acid was converted into benzimidazole bis-heterocycles, via the intermediacy of benzimidazole linked ortho-chloro amines. The amphiphilic reactivity of this intermediate was designed to achieve the title compounds by the reaction of various acid chlorides and isothiocyanates in a single step through the in situ formation of ortho-chloro anilides and thioureas under microwave irradiation. A versatile one pot domino annulation reaction was developed to involve the reaction of benzimidazole linked ortho-chloro amines with acid chlorides and isothiocyanates. The initial acylation and urea formation followed by copper catalyzed intramolecular C-O and C-S cross coupling reactions furnished the angularly oriented bis-heterocycles which bear a close resemblance to the streptomyces antibiotic UK-1. The Royal Society of Chemistry 2013.