1428671-97-9

Upstream product

• 1428671-96-8 (3R,4S)-1-[bis(4-methoxyphenyl)(phenyl)methoxy]-4-(4-cyclohexa-2,4-dien-1-yl-4,5,5-triphenyl-1,3,2-dioxaborolan-2-yl)hex-5-en-3-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 479579-58-3 2-allenyl-4,4,5,5-tetraphenyl-1,3,2-dioxaborolane 

Downstream Products

• 1428671-98-0 (5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol 

Relevant academic research and scientific papers

Enantio- and diastereoselective synthesis of N-acetyl dihydrotetrafibricin methyl ester

A highly diastereoselective synthesis of N-acetyl dihydrotetrafibricin methyl ester (34) is described. The synthesis features three enantioselective double allylboration reactions and an intramolecular hydrosilylation/Fleming- Tamao oxidation sequence to establish seven of the hydroxy-bearing stereocenters of 34. Especially noteworthy is the fragment-assembly double allyboration reaction of 2 and 7 using reagent 3, which provides the advanced intermediate 6 with >20:1 diastereoselectivity.