142872-80-8

Upstream product

• 906371-80-0 (2-chloropyridin-3-yl)-(4-fluorobenzyl)amine 
• 77287-34-4 formamide 
• 459-57-4 4-fluorobenzaldehyde 
• 6298-19-7 2-chloro-3-aminopyridine 

Downstream Products

• 1431659-64-1 2-chloro-1-(4-fluorobenzyl)-1H-imidazo[4,5-b]pyridine 
• 1431659-82-3 4-(1-(4-fluorobenzyl)-1H-imidazo[4,5-b]pyridin-2-yl)morpholine 

Relevant academic research and scientific papers

Substituted benzimidazoles as modulators of Ras signaling

Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

An improved synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b]pyrazines by palladium catalyzed amidation using xantphos in a 1,4-dioxane:tert-amyl alcohol solvent system

Herein an improved protocol for the synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b]pyrazines using a palladium-catalyzed amidation that utilizes Xantphos as an ancillary phosphine ligand is reported. The use of a binary solvent system comprised of

Synthesis of 2-amino-imidazo[4,5-b]pyridines

The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines. The Royal Society of Chemistry 2013.